A NONCATALYZED RING-OPENING AMINOLYSIS REACTION OF SESQUITERPENE LACTONES

被引:15
作者
BLAY, G [1 ]
CARDONA, L [1 ]
GARCIA, B [1 ]
GARCIA, CL [1 ]
PEDRO, JR [1 ]
机构
[1] UNIV VALENCIA,FAC QUIM,DEPT QUIM ORGAN,E-46100 BURJASSOT,SPAIN
关键词
D O I
10.1016/S0040-4039(00)76003-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Santonin (1) and other sesquiterpene lactones (6-10) react cleanly with pyrrolidine at room temperature to afford gamma-hydroxyalkylamides, which by elimination with mesyl chloride in pyridine-benzene at 80 degrees C give unsaturated alkylamides.
引用
收藏
页码:931 / 934
页数:4
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