APPLICATION OF INTEGRAL-EQUATION THEORY TO AQUEOUS 2-PHASE PARTITIONING SYSTEMS

被引:67
作者
HAYNES, CA
BENITEZ, FJ
BLANCH, HW
PRAUSNITZ, JM
机构
[1] LAWRENCE BERKELEY LAB, DEPT CHEM ENGN, BERKELEY, CA 94720 USA
[2] LAWRENCE BERKELEY LAB, DIV CHEM SCI, BERKELEY, CA 94720 USA
关键词
D O I
10.1002/aic.690390913
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
A molecular-thermodynamic model is developed for representing thermodynamic properties of aqueous two-phase systems containing polymers, electrolytes, and proteins. The model is based on McMillan-Mayer solution theory and the generalized mean-spherical approximation to account for electrostatic forces between unlike ions. The Boublik-Mansoori equation of state for hard-sphere mixtures is coupled with the osmotic virial expansion truncated after the second-virial terms to account for short-range forces between molecules. Osmotic second virial coefficients are reported from low-angle laser-light scattering (LALLS) data for binary and ternary aqueous solutions containing polymers and proteins. Ion-polymer specific-interaction coefficients are determined from osmotic-pressure data for aqueous solutions containing a water-soluble polymer and an alkali chloride, phosphate or sulfate salt. When coupled with LALLS and osmotic-pressure data reported here, the model is used to predict liquid-liquid equilibria, protein partition coefficients, and electrostatic potentials between phases for both polymer-polymer and polymer-salt aqueous two-phase systems. For bovine serum albumin, lysozyme, and alpha-chymotrypsin, predicted partition coefficients are in excellent agreement with experiment.
引用
收藏
页码:1539 / 1557
页数:19
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