TYROSINASE INHIBITORY FLAVONOIDS FROM HETEROTHECA INULOIDES AND THEIR STRUCTURAL FUNCTIONS

被引：45

作者：

KUBO, I ^{[1
]}

KINSTHORI, I ^{[1
]}

ISHIGURO, K ^{[1
]}

CHAUDHURI, SK ^{[1
]}

SANCHEZ, Y ^{[1
]}

OGURA, T ^{[1
]}

机构：

[1] UNIV AUTONOMA GUADALAJARA,DEPT QUIM,GUADALAJARA,JALISCO,MEXICO

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80510-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By bioassay-guided fractionations, quercetin was isolated as the principal tyrosinase inhibitor from the dried flowers of Heterotheca inuloides CASS (Compositae). This flavonol inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase (EC 1.14.18.1) with an ID50 of 22 mu g/ml (0.07 mM). Interestingly, quercetin 3-beta-glucoside did not inhibit this oxidation up to 1 mg/ml. Kinetic study have found quercetin to be a characteristic competitive inhibitor for the L-DOPA oxidation by the mushroom tyrosinase. Based on the above findings, several related flavonoids were also examined for comparison.

引用

页码：1443 / 1446

页数：4

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