A NEW TOPOISOMERASE-II INHIBITOR, BE-22179, PRODUCED BY A STREPTOMYCETE .1. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY

被引：33

作者：

OKADA, H ^{[1
]}

SUZUKI, H ^{[1
]}

YOSHINARI, T ^{[1
]}

ARAKAWA, H ^{[1
]}

OKURA, A ^{[1
]}

SUDA, H ^{[1
]}

YAMADA, A ^{[1
]}

UEMURA, D ^{[1
]}

机构：

[1] SHIZUOKA UNIV,FAC LIBERAL ARTS,SHIZUOKA,SHIZUOKA 422,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 02期

关键词：

D O I：

10.7164/antibiotics.47.129

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new topoisomerase II inhibitor, designated BE-22179, was isolated from the culture broth of Streptomyces sp. A22179, which resembles ''Streptomyces gangtokensis''. The inhibitor was extracted from the mycelial cake of the culture broth with organic solvent and successively purified by silica gel chromatography. BE-22179 inhibited topoisomerase II strongly but not topoisomerase I and showed potent antitumor activity against various tumor cell lines both and vitro and in vivo.

引用

页码：129 / 135

页数：7

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