HIGHLY EFFICIENT AND MILD SYNTHESIS OF NITRONES BY CATALYTIC-OXIDATION OF HYDROXYLAMINES WITH TETRA-N-PROPYLAMMONIUM PERRUTHENATE

被引：65

作者：

GOTI, A

DESARLO, F

ROMANI, M

机构：

[1] Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, C.N.R., Dip. di Chimica Organica Ugo Schiff, I-50121 Firenze

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)78275-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of N,N-disubstituted hydroxylamines by N-methylmorpholine N-oxide (NMO) and catalytic amounts of tetra-n-propylammonium perruthenate (TPAP) at room temperature occurs very rapidly to give the corresponding nitrones, which can be trapped by dipolarophiles present in the reaction mixture, in excellent yields. A competitive experiment in the presence of a primary alcohol gave a >50:1 nitrone to aldehyde ratio.

引用

页码：6571 / 6574

页数：4

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