N-(2-HYDROXYETHYL)DOXORUBICIN FROM HYDROLYSIS OF 3'-DEAMINO-3'-(3-CYANO-4-MORPHOLINYL)DOXORUBICIN

被引：6

作者：

ACTON, EM

TONG, GL

SMITH, TH

TAYLOR, DL

STREETER, DG

PETERS, JH

GORDON, GR

FILPPI, JA

WOLGEMUTH, RL

GIULIANI, FC

PENCO, S

机构：

[1] SRI INT,MENLO PK,CA 94025

[2] ADRIA LABS,COLUMBUS,OH 43216

[3] FARMITALIA CARLO ERBA,I-20146 MILAN,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1986年 / 29卷 / 10期

关键词：

D O I：

10.1021/jm00160a057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2120 / 2122

页数：3

共 13 条

[1] NEW CYANOMORPHOLINYL BY-PRODUCT OF DOXORUBICIN REDUCTIVE ALKYLATION [J].

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JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (07) :1225-1230

[2] N-(CYANOMETHYL)ANTHRACYCLINES AND N-(2-METHOXY-1-CYANOETHYL)ANTHRACYCLINES AND RELATED CARBOXYL DERIVATIVES [J].

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[3] INTENSELY POTENT MORPHOLINYL ANTHRACYCLINES [J].

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[4] OXIDATION OF SECONDARY-AMINES TO ALPHA-CYANOAMINES [J].

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[5]

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[6]

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[7]

HORTON D, 1985, CARBOHYDR RES, V94, P11

[8]

ISHIGURO K, 1981, J BIOL CHEM, V256, P2162

[9]

LOWN J W, 1982, Biochemistry, V21, P419, DOI 10.1021/bi00532a001

[10] DISSOCIATION OF ANTITUMOR POTENCY FROM ANTHRACYCLINE CARDIOTOXICITY IN A DOXORUBICIN ANALOG [J].

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SCIENCE, 1985, 228 (4707) :1544-1546

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