CO-INDUCTION OF MICROSOMAL CYTOCHROME-P-452 AND THE PEROXISOMAL FATTY-ACID BETA-OXIDATION PATHWAY IN THE RAT BY CLOFIBRATE AND DI-(2-ETHYLHEXYL)PHTHALATE - DOSE-RESPONSE STUDIES

被引:86
作者
SHARMA, R
LAKE, BG
GIBSON, GG
机构
[1] UNIV SURREY,DEPT BIOCHEM,DIV PHARMACOL & TOXICOL,GUILDFORD GU2 5XH,SURREY,ENGLAND
[2] BRITISH IND BIOL RES ASSOC,CARSHALTON SM5 4DS,SURREY,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1016/0006-2952(88)90771-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1203 / 1206
页数:4
相关论文
共 23 条
[1]   IMMUNOCHEMICAL STUDY ON THE CONTRIBUTION OF HYPOLIPIDEMIC-INDUCED CYTOCHROME-P-452 TO THE METABOLISM OF LAURIC ACID AND ARACHIDONIC-ACID [J].
BAINS, SK ;
GARDINER, SM ;
MANNWEILER, K ;
GILLETT, D ;
GIBSON, GG .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (18) :3221-3229
[3]  
CAPPUZZI DM, 1983, BIOCHEM PHARMACOL, V32, P2195
[4]   REVIEW OF THE HEPATIC RESPONSE TO HYPOLIPEMIC DRUGS IN RODENTS AND ASSESSMENT OF ITS TOXICOLOGICAL SIGNIFICANCE TO MAN [J].
COHEN, AJ ;
GRASSO, P .
FOOD AND COSMETICS TOXICOLOGY, 1981, 19 (05) :585-605
[5]   HEPATIC PEROXISOME PROLIFERATION AND HYPOLIPIDEMIC EFFECTS OF DI(2-ETHYLHEXYL) PHTHALATE IN NEONATAL AND ADULT-RATS [J].
DOSTAL, LA ;
JENKINS, WL ;
SCHWETZ, BA .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 87 (01) :81-90
[6]   PEROXISOME PROLIFERATION DUE TO DI(2-ETHYLHEXYL) PHTHALATE (DEHP) - SPECIES-DIFFERENCES AND POSSIBLE MECHANISMS [J].
ELCOMBE, CR ;
MITCHELL, AM .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1986, 70 :211-219
[7]   CYTOCHROME-P-450 INDUCTION BY CLOFIBRATE - PURIFICATION AND PROPERTIES OF A HEPATIC CYTOCHROME-P-450 RELATIVELY SPECIFIC FOR THE 12-HYDROXYLATION AND 11-HYDROXYLATION OF DODECANOIC ACID (LAURIC-ACID) [J].
GIBSON, GG ;
ORTON, TC ;
TAMBURINI, PP .
BIOCHEMICAL JOURNAL, 1982, 203 (01) :161-168
[8]  
GOULD R. G., 1967, PROGR BJOCHEM PHARMACOL, V2, P345
[9]   PEROXISOME PROLIFERATION IN PRIMARY CULTURES OF RAT HEPATOCYTES [J].
GRAY, TJB ;
LAKE, BG ;
BEAMAND, JA ;
FOSTER, JR ;
GANGOLLI, SD .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1983, 67 (01) :15-25
[10]  
KLUWE WM, 1982, TOXIC ENV HLTH, V10, P797