GENES ENCODING HUMAN SERUM AMYLOID-A PROTEINS SAA1 AND SAA2 ARE LOCATED 18 KB APART IN OPPOSITE TRANSCRIPTIONAL ORIENTATIONS

被引：13

作者：

KLUVEBECKERMAN, B ^{[1
]}

SONG, M ^{[1
]}

机构：

[1] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN 46202

来源：

GENE | 1995年 / 159卷 / 02期

关键词：

ACUTE-PHASE PROTEIN; AMYLOIDOSIS; CHROMOSOME; 11; GENES; GENE MAPPING; COSMID;

D O I：

10.1016/0378-1119(95)00027-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The three expressed genes of the human serum amyloid A gene family (SAA1, SAA2 and SAA4) have been isolated in four contiguous clones selected from a chromosome 11 cosmid library. Analysis of these clones revealed that SAA1 and SAA2 are located 18 kb apart in opposite transcriptional orientations: while SAA4 lies 11 kb downstream from SAA2 in the same orientation: 3'(SAA1)5'-18 kb-5'(SAA2)3'-11 kb-5'(SAA)3'. A fifth SAA clone isolated from this library was noncontiguous with the other four and contained the SAA3 pseudogene.

引用

页码：289 / 290

页数：2

共 10 条

[1] THE HUMAN ACUTE-PHASE SERUM AMYLOID-A GENE FAMILY - STRUCTURE, EVOLUTION AND EXPRESSION IN HEPATOMA-CELLS [J].

BETTS, JC ;

EDBROOKE, MR ;

THAKKER, RV ;

WOO, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1991, 34 (04) :471-482

[2] IDENTIFICATION OF CIS-ACTING SEQUENCES RESPONSIBLE FOR PHORBOL ESTER INDUCTION OF HUMAN-SERUM AMYLOID A GENE-EXPRESSION VIA A NUCLEAR FACTOR KB-LIKE TRANSCRIPTION FACTOR [J].

EDBROOKE, MR ;

BURT, DW ;

CHESHIRE, JK ;

WOO, P .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (05) :1908-1916

[3] LOCALIZATION OF HUMAN SAA GENE(S) TO CHROMOSOME-11 AND DETECTION OF DNA POLYMORPHISMS [J].

KLUVEBECKERMAN, B ;

NAYLOR, SL ;

MARSHALL, A ;

GARDNER, JC ;

SHOWS, TB ;

BENSON, MD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (03) :1196-1204

[4] NONEXPRESSION OF THE HUMAN SERUM AMYLOID-A 3 (SAA3) GENE [J].

KLUVEBECKERMAN, B ;

DRUMM, ML ;

BENSON, MD .

DNA AND CELL BIOLOGY, 1991, 10 (09) :651-661

[5] THE HUMAN-SERUM AMYLOID-A (SAA)-ENCODING GENE GSAA1 - NUCLEOTIDE-SEQUENCE AND POSSIBLE AUTOCRINE-COLLAGENASE-INDUCER FUNCTION [J].

SACK, GH ;

TALBOT, CC .

GENE, 1989, 84 (02) :509-515

[6] A CONSTITUTIVELY EXPRESSED SERUM AMYLOID-A PROTEIN GENE (SAA4) IS CLOSELY LINKED TO, AND SHARES STRUCTURAL SIMILARITIES WITH, AN ACUTE-PHASE SERUM AMYLOID-A PROTEIN GENE (SAA2) [J].

STEEL, DM ;

SELLAR, GC ;

UHLAR, CM ;

SIMON, S ;

DEBEER, FC ;

WHITEHEAD, AS .

GENOMICS, 1993, 16 (02) :447-454

[7] ANALYSIS OF THE GENOMIC AND DERIVED PROTEIN-STRUCTURE OF A NOVEL HUMAN SERUM AMYLOID A GENE, SAA4 [J].

WATSON, G ;

COADE, S ;

WOO, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1992, 36 (05) :703-712

[8]

WHITEHEAD AS, 1992, J BIOL CHEM, V267, P3862

[9]

WOO P, 1987, J BIOL CHEM, V262, P15790

[10]

YAMAMOTO KI, 1987, J IMMUNOL, V139, P1683

← 1 →