Haemophilus influenzae represents a common cause of human disease and an important source of morbidity and mortality. Disease caused by this organism begins with colonization of the upper respiratory tract. Several studies indicate that H. influenzae is capable of binding to and entering cultured human cells, properties which are potentially of relevance to the process of colonization. In the present study, we isolated an H. influenzae gene designated hap, which is associated with the capacity for in vitro attachment and entry. Analysis of the derived amino acid sequence of hap demonstrated significant homology with the serine-type IgA1 proteases expressed by H. influenzae and Neisseria gonorrhoeae. It is notable that the hap product shares the catalytic domain of the IgA1 proteases and appears to be processed and secreted in an analogous manner. We speculate that the hap gene product is an important determinant of colonization, perhaps enabling the organism to evade the local immune response and thereby persist within the respiratory tract.
机构:
INST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCEINST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE
ALLAOUI, A
SANSONETTI, PJ
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INST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCEINST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE
SANSONETTI, PJ
PARSOT, C
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机构:
INST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCEINST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE
机构:
INST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCEINST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE
ALLAOUI, A
SANSONETTI, PJ
论文数: 0引用数: 0
h-index: 0
机构:
INST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCEINST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE
SANSONETTI, PJ
PARSOT, C
论文数: 0引用数: 0
h-index: 0
机构:
INST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCEINST PASTEUR, INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC, 28 RUE DR ROUX, F-75724 PARIS 15, FRANCE