1-ALPHA-HYDROXYARTEETHER, A NEW MICROBIAL TRANSFORMATION PRODUCT

被引：12

作者：

HUFFORD, CD

KHALIFA, SI

ORABI, KY

WIGGERS, FT

KUMAR, R

ROGERS, RD

CAMPANA, CF

机构：

[1] UNIV MISSISSIPPI,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,DEPT MED CHEM,UNIVERSITY,MS 38677

[3] NO ILLINOIS UNIV,DEPT CHEM,DE KALB,IL 60115

[4] SIEMENS IND AUTOMAT INC,MADISON,WI 53719

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 05期

关键词：

D O I：

10.1021/np50119a016

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antimalarial drug arteether [1] was subjected to microbial metabolism using Cunninghamella elegans (ATCC 9245) and Streptomyces lavendulae (L-105). 1 alpha-Hydroxyarteether [2], a novel microbial metabolite of 1 was isolated from the cultures of C, elegans and fully characterized. The stereochemistry of 2 was established by X-ray crystallographic analysis. 9 beta-Hydroxyarteether [3] was isolated from the same culture in a much higher yield (40%) than previously reported (2.2%). Compound 6, a known metabolite of 1, was isolated from the fermentation cultures of S, lavendulae for the first time.

引用

页码：751 / 755

页数：5

共 10 条

[1]

BAKER JK, 1988, BIOMED ENVIRON MASS, V18, P337

[2] ARTEETHER, A NEW ANTIMALARIAL DRUG - SYNTHESIS AND ANTIMALARIAL PROPERTIES [J].