THIN-LAYER CHROMATOGRAPHY OF PANCURONIUM-BROMIDE AND ITS HYDROLYSIS PRODUCTS

被引：11

作者：

KINGET, R ^{[1
]}

MICHOEL, A ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, DEPT PHARM, PRACTICAL & IND PHARM LAB, B-3030 HEVERLE, BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY | 1976年 / 120卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(01)99022-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The degradation of pancuronium bromide ([3.alpha., 17.beta.-diacetoxy 2.beta., 16.beta.-dipiperidino-5.alpha.-androstone dimethobromide] a potent curariform neuromuscular blocking agent of the competitive type) was studied to elucidate the mechanism and the influence of hydrolysis on the preparation and stability of parenteral solutions of the drug. Published separation methods were improved so that pancuronium bromide and its 3 hydrolysis products can be determined quantitatively, no matter in what proportions they are present in a mixture.

引用

页码：234 / 238

页数：5

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