PHARMACOKINETICS AND BIOAVAILABILITY OF INTRAVENOUS AND TOPICAL NITROGLYCERIN IN THE RHESUS-MONKEY - ESTIMATE OF PERCUTANEOUS 1ST-PASS METABOLISM

被引：55

作者：

WESTER, RC ^{[1
]}

NOONAN, PK ^{[1
]}

SMEACH, S ^{[1
]}

KOSOBUD, L ^{[1
]}

机构：

[1] GD SEARLE & CO,SKOKIE,IL 60076

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1983年 / 72卷 / 07期

关键词：

D O I：

10.1002/jps.2600720708

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：745 / 748

页数：4

共 24 条

[1]

BLUMENTHAL HP, 1977, BRIT J CLIN PHARMACO, V4, P241

[2]

DAVIDOV ME, 1977, CLIN RES, V25, pA545

[3] SITE DEPENDENCE FOR TOPICAL ABSORPTION OF NITROGLYCERIN IN RATS [J].

HORHOTA, ST ;

FUNG, HL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (09) :1345-1346

[4] ANGINA-PECTORIS - CURRENT APPROACH TO TREATMENT [J].

IKRAM, H .

DRUGS, 1979, 18 (02) :130-136

[5] ANTIANGINAL DRUGS [J].

KAVERINA, NV ;

CHUMBURIDZE, VB .

PHARMACOLOGY & THERAPEUTICS, 1979, 4 (01) :109-153

[6] GASTROINTESTINAL ABSORPTION OF ORGANIC NITRATES [J].

KRANTZ, JC ;

LEAKE, CD .

AMERICAN JOURNAL OF CARDIOLOGY, 1975, 36 (03) :407-408

[7] METHOD OF PREPARATION AND APPLICATION OF SMALL QUANTITIES OF SEMISOLID TOPICALS [J].

LINDSAY, C ;

FELDMANN, R ;

MAIBACH, H .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 1976, 257 (01) :89-91

[8]

MAIERLENZ VH, 1980, ARZNEIMFORSCH DRUG R, V30, P320

[9] PLASMA CONCENTRATIONS OF ISOSORBIDE DINITRATE AFTER CUTANEOUS AND SUB-LINGUAL DOSES TO HUMAN SUBJECTS [J].

MANSELJONES, D ;

TAYLOR, T ;

DOYLE, E ;

CHASSEAUD, LF ;

DARRAGH, A ;

OKELLY, DA ;

OVER, H .

JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 18 (11-1) :544-548

[10]

METZLER CM, 1974, BIOMETRICS, V30, P562

← 1 2 3 →