PHARMACOKINETIC STUDY OF OXYTETRACYCLINE IN FISH .1. ABSORPTION, DISTRIBUTION AND ACCUMULATION IN RAINBOW-TROUT IN FRESH-WATER

被引：62

作者：

ROGSTAD, A ^{[1
]}

HORMAZABAL, V ^{[1
]}

ELLINGSEN, OF ^{[1
]}

RASMUSSEN, KE ^{[1
]}

机构：

[1] NORWEGIAN COLL VET MED,DEPT FOOD HYG,N-0033 OSLO 1,NORWAY

来源：

AQUACULTURE | 1991年 / 96卷 / 3-4期

关键词：

D O I：

10.1016/0044-8486(91)90151-V

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The absorption, distribution and elimination of oxytetracycline in plasma, muscle, liver, intestine, mucus, skin and vertebrae in rainbow trout in freshwater were studied after a single dose of 150 mg/kg fish. The absorption of the drug was slow and only about 2.6% of the administered dose was absorbed at the time of maximum absorption. The distribution to all tissues of the fish was good, and a considerable affinity of OTC to tissues was observed. The slow elimination was demonstrated by the long half-life which was 11.6 days from plasma.

引用

页码：219 / 226

页数：8

共 11 条

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