SEQUENCE AND CHROMOSOME ASSIGNMENT TO 11P13-P12 OF HUMAN RAG GENES

被引：35

作者：

ICHIHARA, Y ^{[1
]}

HIRAI, M ^{[1
]}

KUROSAWA, Y ^{[1
]}

机构：

[1] UNIV TOKYO,FAC SCI,DEPT ANTHROPOL,TOKYO 113,JAPAN

来源：

IMMUNOLOGY LETTERS | 1992年 / 33卷 / 03期

关键词：

RECOMBINASE; CHROMOSOME MAPPING; FLUORESCENCE INSITU HYBRIDIZATION;

D O I：

10.1016/0165-2478(92)90073-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recombination-activating genes RAG-1 and RAG-2 are required for V(D)J DNA rearrangements at loci for immunoglobulin and T cell receptor genes. We isolated the human RAG-2 gene and determined its nucleotide sequence. Mapping analysis of RAG-1 and RAG-2 genes on human chromosomes by fluorescence in situ hybridization indicated that the genes are located on chromosome 11p13-p12. RAG-1 and RAG-2 do not seem to be linked to any of the primary immunodeficiencies for which defective genes have already been mapped.

引用

页码：277 / 284

页数：8

共 27 条

[1] SCREENING GAMMAGT RECOMBINANT CLONES BY HYBRIDIZATION TO SINGLE PLAQUES INSITU
BENTON, WD
DAVIS, RW
[J]. SCIENCE, 1977, 196 (4286) : 180 - 182
[2] EXPRESSION OF HUMAN RECOMBINATION ACTIVATING GENES (RAG1 AND RAG2) IN NEOPLASTIC LYMPHOID-CELLS - CORRELATION WITH CELL-DIFFERENTIATION AND ANTIGEN RECEPTOR EXPRESSION
BORIES, JC
CAYUELA, JM
LOISEAU, P
SIGAUX, F
[J]. BLOOD, 1991, 78 (08) : 2053 - 2061
[3] SELECTIVE EXPRESSION OF RAG-2 IN CHICKEN B-CELLS UNDERGOING IMMUNOGLOBULIN GENE CONVERSION
CARLSON, LM
OETTINGER, MA
SCHATZ, DG
MASTELLER, EL
HURLEY, EA
MCCORMACK, WT
BALTIMORE, D
THOMPSON, CB
[J]. CELL, 1991, 64 (01) : 201 - 208
[4] THE RECOMBINATION ACTIVATING GENE-1 (RAG-1) TRANSCRIPT IS PRESENT IN THE MURINE CENTRAL-NERVOUS-SYSTEM
CHUN, JJM
SCHATZ, DG
OETTINGER, MA
JAENISCH, R
BALTIMORE, D
[J]. CELL, 1991, 64 (01) : 189 - 200
[5] LOCALIZATION OF AN ATAXIA-TELANGIECTASIA GENE TO CHROMOSOME 11Q22-23
GATTI, RA
BERKEL, I
BODER, E
BRAEDT, G
CHARMLEY, P
CONCANNON, P
ERSOY, F
FOROUD, T
JASPERS, NGJ
LANGE, K
LATHROP, GM
LEPPERT, M
NAKAMURA, Y
OCONNELL, P
PATERSON, M
SALSER, W
SANAL, O
SILVER, J
SPARKES, RS
SUSI, E
WEEKS, DE
WEI, S
WHITE, R
YODER, F
[J]. NATURE, 1988, 336 (6199) : 577 - 580
[6] ABNORMALITIES IN DNA REARRANGEMENTS OF IMMUNOGLOBULIN GENE LOCI IN PRECURSOR B-CELLS DERIVED FROM X-LINKED AGAMMAGLOBULINEMIA PATIENT AND A SEVERE COMBINED IMMUNODEFICIENCY PATIENT
ICHIHARA, Y
MATSUOKA, H
TSUGE, I
OKADA, J
TORII, S
YASUI, H
KUROSAWA, Y
[J]. IMMUNOGENETICS, 1988, 27 (05) : 330 - 337
[7] JASPERS NGJ, 1988, AM J HUM GENET, V42, P66
[8] GENETIC COMPLEMENTATION ANALYSIS OF ATAXIA TELANGIECTASIA AND NIJMEGEN BREAKAGE SYNDROME - A SURVEY OF 50 PATIENTS
JASPERS, NGJ
GATTI, RA
BAAN, C
LINSSEN, PCML
BOOTSMA, D
[J]. CYTOGENETICS AND CELL GENETICS, 1988, 49 (04): : 259 - 263
[9] REPORT OF THE COMMITTEE-ON-THE-GENETIC-CONSTITUTION-OF-CHROMOSOME-11
JUNIEN, C
VANHEYNINGEN, V
[J]. CYTOGENETICS AND CELL GENETICS, 1990, 55 (1-4): : 153 - 169
[10] RESTORATION OF RADIATION-RESISTANCE IN ATAXIA TELANGIECTASIA CELLS BY THE INTRODUCTION OF NORMAL HUMAN CHROMOSOME-11
KOMATSU, K
KODAMA, S
OKUMURA, Y
KOI, M
OSHIMURA, M
[J]. MUTATION RESEARCH, 1990, 235 (02): : 59 - 63

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