EVIDENCE FOR ABROGATION OF ONCOGENE-INDUCED RADIORESISTANCE OF MAMMARY-CANCER CELLS BY HEXADECYLPHOSPHOCHOLINE IN-VITRO

被引：19

作者：

BRUYNEEL, EA

STORME, GA

SCHALLIER, DCC

VANDENBERGE, DL

HILGARD, P

MAREEL, MM

机构：

[1] UNIV HOSP GHENT, DEPT RADIOTHERAPY NUCL MED & EXPTL CANCEROL, B-9000 GHENT, BELGIUM

[2] FREE UNIV BRUSSELS, ACAD HOSP, CTR ONCOL, DEPT RADIOTHERAPY, BRUSSELS, BELGIUM

[3] ASTA MED AG, W-6000 FRANKFURT, GERMANY

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 14期

关键词：

D O I：

10.1016/0959-8049(93)90452-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hexadecylphosphocholine (HePC), an experimental and clinical antitumour agent of the alkyllysophospholipid group, was tested for its radiosensitising effect on a panel of nine human mammary cancer cell lines in vitro. Growth inhibition by ionising radiation and recovery from it were not influenced by pretreatment with HePC in most cases, except for two cell lines expressing an activated ras oncogene. In the latter we found an enhanced radioresistance that was abolished by pretreatment with HePC. Our results suggest that HePC may act as a radiosensitiser for cells carrying an activated ras oncogene.

引用

页码：1958 / 1963

页数：6

共 30 条

[1] RETINOIC ACID MODULATES BOTH INVASION AND PLASMA-MEMBRANE RUFFLING OF MCF-7 HUMAN MAMMARY-CARCINOMA CELLS-INVITRO [J].