QSAR OF HIV INHIBITORS

被引：18

作者：

HANSCH, C

ZHANG, LT

机构：

[1] Department of Chemistry, Pomona College, Claremont

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80640-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quantitative structure-activity relationships (QSAR) have been derived for two sets of HIV inhibitors: 1-[2-hydroxyethoxy)methyl]-6-(X-phenylthio)thymines and thiothymines and dideoxypurine ribofuranosides. It is found that the hydrophobic and especially the steric properties of substituents determine relative potencies of the derivatives.

引用

页码：1165 / 1169

页数：5

共 8 条

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