A SIMPLE PROCEDURE FOR THE SYNTHESIS OF 3-(SUBSTITUTED-SULFANYL)-4-HYDROXY-6-SUBSTITUTED-PYRAN-2-ONES

被引：10

作者：

PARA, KS

ELLSWORTH, EL

PRASAD, JVN

机构：

[1] Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan, 48106

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1002/jhet.5570310657

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3-(substituted sulfanyl)-4-hydroxy-6-substituted-pyran-2-ones were synthesized for Human immunodeficiency virus-1 protease inhibition. These compounds were synthesized in a simple and convergent fashion to allow us a rapid preparation of many structurally diversified analogues. Thus the condensation of trimethylsilyl enol ethers of corresponding ketones, with 2-(S-substituted)propane-1,3-dioates afforded the corresponding pyrones in 24-70% isolated yields.

引用

页码：1619 / 1624

页数：6