DOES AUTOCRINE GROWTH-FACTOR SECRETION FORM PART OF A MECHANISM WHICH PARADOXICALLY PROTECTS AGAINST TUMOR-DEVELOPMENT

被引：16

作者：

DAWSON, T ^{[1
]}

WYNFORDTHOMAS, D ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT PATHOL,CRC,THYROID TUMOUR BIOL RES GRP,CARDIFF CF4 4XN,S GLAM,WALES

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 06期

关键词：

AUTOCRINE CIRCUITS; GROWTH FACTORS; IGF-I; TUMORIGENESIS;

D O I：

10.1038/bjc.1995.222

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autocrine growth factor secretion has classically been considered as a mechanism by which tumour cells achieve autonomous growth. However, there is now considerable evidence that autocrine circuits operate in the growth regulation of normal adult tissues. Here we consider the possible advantages to the normal epithelial cell of utilising such an external growth factor circuit and suggest that autocrine growth factor secretion, when viewed in a multicellular context, could paradoxically form part of a mechanism for preventing tumour development.

引用

页码：1136 / 1141

页数：6

共 33 条

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