HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC RESOLUTION OF RACEMIC 1,4-BENZODIAZEPIN-2-ONES BY MEANS OF A BETA-CYCLODEXTRIN SILICA BONDED CHIRAL STATIONARY PHASE

被引：25

作者：

BERTUCCI, C

DOMENICI, E

UCCELLOBARRETTA, G

SALVADORI, P

机构：

[1] UNIV PISA,CNR,CTR STUDIO MACROMOLEC STEREORDINATE & OTTICAMENTE ATT,DIPARTIMENTO CHIM & CHIM IND,I-56126 PISA,ITALY

[2] SCUOLA NORMALE SUPER PISA,I-56100 PISA,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 506卷

关键词：

D O I：

10.1016/S0021-9673(01)91610-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A bonded β-cyclodextrin chiral stationary phase was used for the chromatographic resolution of a series of 1,4-benzodiazepin-2-ones (BDZs). This column can also be employed for the direct resolution of ionic BDZs as the hemisuccinate esters of 3-hydroxy-BDZs. Nuclear magnetic resonance spectroscopy was used to obtain preliminary information on the mechanism of chiral discrimination. © 1990.

引用

页码：617 / 625

页数：9

共 23 条

[1] OPTICAL RESOLUTION BY LIQUID-CHROMATOGRAPHY ON IMMOBILIZED BOVINE SERUM-ALBUMIN
ALLENMARK, S
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3): : 425 - 442
[2] Andersen F.M., 1982, ARCH PHARM CHEMI SCI, V10, P80
[3] ANGYAN J, 1980, MAGYAR KEM L, V35, P307
[4] BABBINI M, 1969, ARZNEI-FORSCHUNG, V19, P1931
[5] CHIRAL STATIONARY PHASES AND CIRCULAR-DICHROISM DETECTION IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - DETERMINATION OF STEREOCHEMICAL PURITY OF DRUGS
BERTUCCI, C
ROSINI, C
PINI, D
SALVADORI, P
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1987, 5 (02) : 171 - 176
[6] CHROMATOGRAPHIC RESOLUTION OF RACEMATES
BLASCHKE, G
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1980, 19 (01): : 13 - 24
[7] BLASCHKE G, 1986, ARZNEIMITTEL-FORSCH, V36-1, P893
[8] BLASCHKE G, 1986, J LIQ CHROMATOGR, V9, P359
[9] STEREOCHEMISTRY OF ENZYMIC 3-HYDROXYLATION OF 1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONES
CORBELLA, A
GARIBOLDI, P
JOMMI, G
FORGIONE, A
MARCUCCI, F
MARTELLI, P
MUSSINI, E
MAURI, F
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (19) : 721 - 722
[10] COMPUTER-AIDED OPTIMIZATION OF DRUG ENANTIOMER SEPARATION IN CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
FELL, AF
NOCTOR, TAG
MAMA, JE
CLARK, BJ
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 434 (02): : 377 - 384

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