CURRENT STATUS OF THE GENE-TOX PROGRAM

被引：10

作者：

AULETTA, AE ^{[1
]}

BROWN, M ^{[1
]}

WASSOM, JS ^{[1
]}

CIMINO, MC ^{[1
]}

机构：

[1] OAK RIDGE NATL LAB,DIV HUMAN GENOME & TOXICOL,OAK RIDGE,TN 37831

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1991年 / 96卷

关键词：

D O I：

10.2307/3431204

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The U.S. Environmental Protection Agency's Gene-Tox Program is a multiphased effort to review and evaluate the existing literature in assay systems available in the field of genetic toxicology. The first phase of the Gene-Tox Program selected assay systems for evaluation, generated expert panel reviews of the data from the scientific literature, and recommended testing protocols for the systems. Phase II established and evaluated the database of chemical genetic toxicity data for its relevance to identifying human health hazards. The ongoing phase III continues reviewing and updating chemical data in selected assay systems. Currently, data exist on over 4000 chemicals in 27 assay systems; two additional assay systems will be included in phase III. The review data are published in the scientific literature and are also publicly available through the National Library of Medicine TOXNET system. The review and analysis components of Gene-Tox comprise 45 published papers, and several others are in preparation. Differences that have been observed between Gene-Tox and National Toxicology Program databases relative to the sensitivity, specificity, accuracy, and predictivity of genetic toxicity data compared to carcinogenesis data are ascribable to differences between the two databases in chemical selection criteria, testing protocols, and chemical class distributions.

引用

页码：33 / 36

页数：4

共 6 条

[1] DEVELOPMENTAL STATUS OF BIOASSAYS IN GENETIC TOXICOLOGY - A REPORT OF PHASE-II OF THE UNITED-STATES-ENVIRONMENTAL-PROTECTION-AGENCY GENE-TOX PROGRAM [J].

BRUSICK, D ;

AULETTA, A .

MUTATION RESEARCH, 1985, 153 (1-2) :1-10

[2]

NESNOW S, 1907, MUTAT RES, V185, P1

[3] AN APPROACH TO IDENTIFYING SPECIALIZED BATTERIES OF BIOASSAYS FOR SPECIFIC CLASSES OF CHEMICALS - CLASS ANALYSIS USING MUTAGENICITY AND CARCINOGENICITY RELATIONSHIPS AND PHYLOGENETIC CONCORDANCE AND DISCORDANCE PATTERNS .1. COMPOSITION AND ANALYSIS OF THE OVERALL DATABASE - A REPORT OF PHASE-II OF THE US-ENVIRONMENTAL-PROTECTION-AGENCY GENE-TOX PROGRAMO [J].

RAY, VA ;

KIER, LD ;

KANNAN, KL ;

HAAS, RT ;

AULETTA, AE ;

WASSOM, JS ;

NESNOW, S ;

WATERS, MD .

MUTATION RESEARCH, 1987, 185 (03) :197-241

[4] A REPORT OF THE UNITED-STATES-ENVIRONMENTAL-PROTECTION-AGENCY GENE-TOX PROGRAM - EVALUATION OF MUTAGENICITY ASSAYS FOR PURPOSES OF GENETIC RISK ASSESSMENT [J].

RUSSELL, LB ;

AARON, CS ;

DESERRES, F ;

GENEROSO, WM ;

KANNAN, KL ;

SHELBY, M ;

SPRINGER, J ;

VOYTEK, P .

MUTATION RESEARCH, 1984, 134 (2-3) :143-157

[5] PREDICTION OF CHEMICAL CARCINOGENICITY IN RODENTS FROM INVITRO GENETIC TOXICITY ASSAYS [J].

TENNANT, RW ;

MARGOLIN, BH ;

SHELBY, MD ;

ZEIGER, E ;

HASEMAN, JK ;

SPALDING, J ;

CASPARY, W ;

RESNICK, M ;

STASIEWICZ, S ;

ANDERSON, B ;

MINOR, R .

SCIENCE, 1987, 236 (4804) :933-941

[6] EVALUATION OF 4 INVITRO GENETIC TOXICITY TESTS FOR PREDICTING RODENT CARCINOGENICITY - CONFIRMATION OF EARLIER RESULTS WITH 41 ADDITIONAL CHEMICALS [J].

ZEIGER, E ;

HASEMAN, JK ;

SHELBY, MD ;

MARGOLIN, BH ;

TENNANT, RW .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1990, 16 :1-14

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