COPPER-MEDIATED ALPHA-HYDROXYLATION OF N-SALICYLOYL-GLYCINE - A MODEL FOR PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE (PAM)

被引：31

作者：

CAPDEVIELLE, P

MAUMY, M

机构：

[1] Laboratoire de recherches organiques de 1' ESPCI, associé au CNRS, F-75231 Paris Cedex 05

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 31期

关键词：

COPPER-CATALYZED GLYCINE ALPHA-HYDROXYLATION; DIOXYGEN; PEROXIDE; TRIMETHYLAMINE OXIDE; PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE;

D O I：

10.1016/S0040-4039(00)79387-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Title compound 1 is selectively hydroxylated in alpha-position by three distinct copper-containing oxidant systems, involving dioxygen, peroxide anion or trimethylamine oxide. Trivalent copper is likely the key intermediate in this first reported model for the PHM activity of enzyme PAM.

引用

页码：3831 / 3834

页数：4

共 11 条

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