HUMAN LYMPHOCYTE ANTIGEN CD38 CATALYZES THE PRODUCTION OF CYCLIC ADP-RIBOSE

被引：81

作者：

SUMMERHILL, RJ ^{[1
]}

JACKSON, DG ^{[1
]}

GALIONE, A ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,DEPT MOLEC IMMUNOL,OXFORD OX3 9DU,ENGLAND

来源：

FEBS LETTERS | 1993年 / 335卷 / 02期

关键词：

CYCLIC ADP-RIBOSE; CD38; ADP-RIBOSYL CYCLASE; NAD(+) GLYCOHYDROLASE; NADASE;

D O I：

10.1016/0014-5793(93)80735-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human lymphocyte antigen CD38 has been shown to share sequence homology with ADP-ribosyl cyclase, the enzyme that catalyzes the conversion of NAD(+) to cyclic ADP-ribose (cADPR), a potent Ca2+-mobilizing agent. In this study COSl cells from African Green Monkey kidney were transiently transfected with CD38 cDNA, inducing expression of authentic CD38 on the cell surface. We demonstrate that CD38 expressed in this manner can convert NAD(+) to cADPR in the extracellular medium as assessed by Ca2+ release from sea-urchin egg microsomes.

引用

页码：231 / 233

页数：3

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