ABUNDANT EXPRESSION OF GLUT1 AND GLUT3 IN RAT EMBRYO DURING THE EARLY ORGANOGENESIS PERIOD

被引：43

作者：

MATSUMOTO, K ^{[1
]}

AKAZAWA, S ^{[1
]}

ISHIBASHI, M ^{[1
]}

TROCINO, RA ^{[1
]}

MATSUO, H ^{[1
]}

YAMASAKI, H ^{[1
]}

YAMAGUCHI, Y ^{[1
]}

NAGAMATSU, S ^{[1
]}

NAGATAKI, S ^{[1
]}

机构：

[1] KYORIN UNIV,SCH MED,DEPT BIOCHEM,TOKYO 181,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The developmental change of both GLUT1 and GLUT3 protein in rat embryonal and fetal brain was examined using Western blot analysis and immunohistochemistry. The brains were collected from fetuses (gestational days 10 to 20), newborn, and adult rats. On day 10, the levels of GLUT1 and GLUT3 expressions were twofold higher than those of adult levels, but thereafter decreased rapidly as the gestation progressed. The tissue distribution of GLUT1 and GLUT3 in embryo was apparently distinct. On day 10, GLUT1 was expressed in the neural tube, gut, heart and optic vesicle, while GLUT3 was expressed in the surface ectoderm and gut. Thus, high affinity glucose transporters may be required in the early organogenesis period because their energy requirement is completely dependent upon anaerobic glycolysis. GLUT3 may facilitate glucose transfer from amniotic fluid to the embryo and GLUT1 may supply glucose for use as an embryonal fuel. (C) 1995 Academic Press, Inc.

引用

页码：95 / 102

页数：8

共 26 条

[1] EFFECTS OF BRIEF EXPOSURE TO INSULIN-INDUCED HYPOGLYCEMIC SERUM DURING ORGANOGENESIS IN RAT EMBRYO CULTURE [J].