A FACILE AND REGIOSPECIFIC TRITIATION OF SPHINGOSINE - SYNTHESIS OF (2S,3R,4E)-2-AMINO-4-OCTADECENE-1,3-DIOL-1-H-3

被引：53

作者：

TOYOKUNI, T ^{[1
]}

NISAR, M ^{[1
]}

DEAN, B ^{[1
]}

HAKOMORI, S ^{[1
]}

机构：

[1] UNIV WASHINGTON, SEATTLE, WA 98119 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 05期

关键词：

DEUTERIUM; TRITIUM; SPHINGOSINE; N; N-DIMETHYLSPHINGOSINE; N-TRIMETHYLSPHINGOSINE;

D O I：

10.1002/jlcr.2580290508

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An easy technique for introduction of tritium into 1-position of sphingosine was developed, employing regiospecific oxidation of the primary hydroxy group followed by reduction with NaB3H4. An improved preparation of N,N-dimethylsphingosine and its quaternization are also described.

引用

页码：567 / 574

页数：8

共 31 条

[1] OXIDATION OF DIOLS WITH ALKALI HYPOCHLORITES CATALYZED BY OXAMMONIUM SALTS UNDER 2-PHASE CONDITIONS [J].