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CHROMOSOMAL LOCALIZATION OF HUMAN AND RAT A-ALPHA-FIBRINOGEN, B-BETA-FIBRINOGEN, AND GAMMA-FIBRINOGEN GENES BY INSITU HYBRIDIZATION

被引：55
作者：
MARINO, MW
FULLER, GM
ELDER, FFB
机构：
[1] UNIV TEXAS, MED BRANCH, DEPT PEDIAT, C335 CHILD HLTH CTR, GALVESTON, TX 77550 USA
[2] UNIV TEXAS, MED BRANCH, DEPT HUMAN BIOL, GALVESTON, TX 77550 USA
[3] UNIV TEXAS, MED BRANCH, DEPT GENET, GALVESTON, TX 77550 USA
来源：
CYTOGENETICS AND CELL GENETICS | 1986年 / 42卷 / 1-2期
关键词：
D O I：
10.1159/000132248
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In situ hybridization of radiolabeled fibrinogen cDNAs to human and rat metaphase chromosomes has shown that the genes encoding the A.alpha., B.beta., and .gamma. fibrinogen subunits are syntenic in both species. Our data localize the human fibrinogen gene cluster to band q31 on chromosome 4, thereby confirming and extending previous map assignments of these genes in man. We have also assigned these genes to the q31 .fwdarw. q34 region of rat chromosome 2. This is the first map assignment of these genes in the rat and also the first report to clearly establish linkage of the B.beta. subunit gene to the A.alpha. and .gamma. genes in this species.
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页码：36 / 41
页数：6
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