COEXPRESSION OF NEUROTROPHINS AND THEIR RECEPTORS IN NEURONS OF THE CENTRAL-NERVOUS-SYSTEM

被引：238

作者：

KOKAIA, Z ^{[1
]}

BENGZON, J ^{[1
]}

METSIS, M ^{[1
]}

KOKAIA, M ^{[1
]}

PERSSON, H ^{[1
]}

LINDVALL, O ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT MED CHEM,MOLEC NEUROBIOL LAB,S-10401 STOCKHOLM 60,SWEDEN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 14期

关键词：

IN-SITU HYBRIDIZATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; BRAIN DAMAGE; HIPPOCAMPUS; EPILEPSY;

D O I：

10.1073/pnas.90.14.6711

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neuronal survival molecules which utilize the Trk family of tyrosine kinase receptors. Using double-label in situ hybridization, we demonstrate that mRNAs for BDNF and its high-affinity receptor TrkB are coexpressed in hippocampal and cortical neurons. Also, a large number of neurons in these areas coexpress NGF and BDNF mRNAs. Epileptic seizures lead to increased levels of both BDNF/TrkB and NGF/BDNF mRNAs in double-labeled cells. Our results show that individual neurons of the central nervous system can coexpress neurotrophins and their receptors and produce two neurotrophic factors. These factors could support neuronal survival after brain insults, not only via retrograde transport but also through autocrine mechanisms.

引用

页码：6711 / 6715

页数：5

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