CIRCULATING AUTOANTIBODIES AGAINST CENTRAL-NERVOUS-SYSTEM (CNS) ANTIGENS IN NEUROLOGICAL DISEASES

被引:7
作者
GIOMETTO, B [1 ]
BOZZA, F [1 ]
FARESIN, F [1 ]
PERON, C [1 ]
ARGENTIERO, V [1 ]
GALLO, P [1 ]
TAVOLATO, B [1 ]
机构
[1] UNIV PADUA,SCUOLA MED,IST NEUROL,NEUROL CLIN 2,VIA VENDRAMINI 7,I-35137 PADUA,ITALY
来源
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1994年 / 15卷 / 04期
关键词
ANTINEURONAL AUTOANTIBODIES; PARANEOPLASTIC CEREBELLAR DEGENERATION; STIFF-MAN SYNDROME;
D O I
10.1007/BF02339320
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A number of investigators have reported the detection of circulating autoantibodies directed against serum and cerebrospinal fluid (CSF) neuronal antigens in certain neurological clinical conditions. Using an immunohistochemical technique, we examined the sera and (when available) the CSF from 120 patients with several neurological disorders and 40 controls in order to analyze the incidence and specificity of the detection of these autoantibodies. Circulating autoantibodies were found in 3 patients with cerebellar degeneration and in 3 patients with stiff-man syndrome, and different staining patterns were revealed in the same disease. Our findings confirm the reported disease-specificity of the detection of these autoantibodies in biological fluids, suggesting that a standardized immunohistochemical technique could constitute an easy and reproducible diagnostic tool in selected neurological conditions. These procedures enable the identification of an immunological pathogenesis of the disease and, in some case, early cancer detection. When atypical staining patterns of staining are found at immunohistochemistry, Western blot characterization of the recognized neuronal antigens is recommended.
引用
收藏
页码:177 / 182
页数:6
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