ISOLATION AND MAPPING OF A HUMAN GENE (PDCD2) THAT IS HIGHLY HOMOLOGOUS TO RP8, A RAT GENE ASSOCIATED WITH PROGRAMMED CELL-DEATH

被引：31

作者：

KAWAKAMI, T

FURUKAWA, Y

SUDO, K

SAITO, H

TAKAMI, S

TAKAHASHI, E

NAKAMURA, Y

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN

[2] OTSUKA PHARMACEUT CO LTD,DIV DIAGNOST,TOKUSHIMA 77101,JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 71卷 / 01期

关键词：

D O I：

10.1159/000134058

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

From a human fetal lung cDNA library we isolated and characterized a human cDNA highly homologous to Rp8, a rat gene associated with programmed cell death. This cDNA, termed PDCD2 (programmed cell death-2), contained an open reading frame of 1032 nucleotides encoding 344 amino acids; it revealed 81% identity in DNA sequence and 83% identity in amino acid sequence with rat Rp8. The gene represented by PDCD2 was expressed in all human tissues examined. We assigned the PDCD2 locus to chromosomal band 6q27 by fluorescence in situ hybridization (FISH).

引用

页码：41 / 43

页数：3

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