INVOLVEMENT OF ACHERGIC SYSTEMS IN CHLORDIAZEPOXIDE INDUCED IMPAIRMENT OF PASSIVE-AVOIDANCE RESPONSE

被引：10

作者：

NABESHIMA, T ^{[1
]}

TOHYAMA, K ^{[1
]}

KAMEYAMA, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT HOSP PHARM,NAGOYA,AICHI 464,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 117卷 / 1-2期

关键词：

Acetylcholine level; Chlordiazepoxide; Mouse; Passive avoidance response; Physostigmine; Ro; 15-4513; Scopolamine;

D O I：

10.1016/0304-3940(90)90144-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems. © 1990.

引用

页码：200 / 206

页数：7

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