C-FOS INDUCTION BY ESTROGEN IN SPECIFIC RAT-BRAIN AREAS

被引：61

作者：

CATTANEO, E ^{[1
]}

MAGGI, A ^{[1
]}

机构：

[1] INST PHARMACOL SCI,MILANO MOLEC PHARMACOL LAB,I-20131 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1990年 / 188卷 / 2-3期

关键词：

ESTROGEN-INDUCIBLE GENES; C-FOS GENE; CNS; STEROID HORMONES;

D O I：

10.1016/0922-4106(90)90050-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was undertaken to determine whether estrogen modulates the expression of the c-fos gene in the CNS of rats. The analysis of the levels of c-fos mRNA was performed by slot blot assay. Administration of estradiol to ovariectomized rats determined a rapid and transient increase in the levels of c-fos mRNA in rat mid-brain and hippocampus, but not in the cerebellum (a brain area which does not express estrogen receptors). Such a change in the levels of c-fos mRNA was not observed after administration of alpha-estradiol or other steroid hormones. The presence of an estrogen responsive element-like sequence, revealed in the 5' flanking region of the murine c-fos gene, strengthens the hypothesis that c-fos gene transcription is directly enhanced by the interaction of the estrogen receptor complex with the promoter region of the proto-oncogene.

引用

页码：153 / 159

页数：7

共 24 条

[1]

CURRAN T, 1984, CELL, V36, P259

[2] NUCLEOPROTEIN COMPLEXES THAT REGULATE GENE-EXPRESSION IN ADIPOCYTE DIFFERENTIATION - DIRECT PARTICIPATION OF C-FOS [J].

DISTEL, RJ ;

RO, HS ;

ROSEN, BS ;

GROVES, DL ;

SPIEGELMAN, BM .

CELL, 1987, 49 (06) :835-844

[3] KINDLING STIMULATION INDUCES C-FOS PROTEIN(S) IN GRANULE CELLS OF THE RAT DENTATE GYRUS [J].

DRAGUNOW, M ;

ROBERTSON, HA .

NATURE, 1987, 329 (6138) :441-442

[4] THE FOS COMPLEX AND FOS-RELATED ANTIGENS RECOGNIZE SEQUENCE ELEMENTS THAT CONTAIN AP-1 BINDING-SITES [J].

FRANZA, BR ;

RAUSCHER, FJ ;

JOSEPHS, SF ;

CURRAN, T .

SCIENCE, 1988, 239 (4844) :1150-1153

[5] RIBONUCLEIC-ACID ISOLATED BY CESIUM-CHLORIDE CENTRIFUGATION [J].

GLISIN, V ;

CRKVENJAKOV, R ;

BYUS, C .

BIOCHEMISTRY, 1974, 13 (12) :2633-2637

[6] REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN [J].

GLOWINSKI, J ;

IVERSEN, LL .

JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) :655-+

[7] THE LONG AND THE SHORT OF LONG-TERM-MEMORY - A MOLECULAR FRAMEWORK [J].

GOELET, P ;

CASTELLUCCI, VF ;

SCHACHER, S ;

KANDEL, ER .

NATURE, 1986, 322 (6078) :419-422

[8] STIMULATION OF NEURONAL ACETYLCHOLINE-RECEPTORS INDUCES RAPID GENE-TRANSCRIPTION [J].

GREENBERG, ME ;

ZIFF, EB ;

GREENE, LA .

SCIENCE, 1986, 234 (4772) :80-83

[9]

JORDAN VC, 1984, PHARMACOL REV, V36, P245

[10] AN ESTROGEN-RESPONSIVE ELEMENT DERIVED FROM THE 5' FLANKING REGION OF THE XENOPUS VITELLOGENIN A2 GENE FUNCTIONS IN TRANSFECTED HUMAN-CELLS [J].

KLEINHITPASS, L ;

SCHORPP, M ;

WAGNER, U ;

RYFFEL, GU .

CELL, 1986, 46 (07) :1053-1061

← 1 2 3 →