GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RESTRICTS GROWTH OF TUBERCLE-BACILLI IN HUMAN MACROPHAGES

被引：52

作者：

DENIS, M ^{[1
]}

GHADIRIAN, E ^{[1
]}

机构：

[1] MCGILL UNIV,MONTREAL GEN HOSP,RES INST,CTR STUDY HOST RESISTANCE,MONTREAL H3G 1A4,QUEBEC,CANADA

来源：

IMMUNOLOGY LETTERS | 1990年 / 24卷 / 03期

关键词：

Granulocyte-macrophage colony-stimulating factor; Human macrophage; Mycobacterium tuberculosis;

D O I：

10.1016/0165-2478(90)90049-V

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of human recombinant granulocyte-macrophage colony stimulating factor (GM-CSF) on the uptake and intracellular growth of Mycobacterium tuberculosis in human macrophages was investigated. GM-CSF was found to reduce growth of M. tuberculosis in human monocyte-derived macrophage in vitro, as compared to untreated cells. The decrease in intracellular growth of the tubercle bacilli did not depend on generation of reactive oxygen species, inasmuch as treatment with scavengers did not affect the ability of GM-CSF to restrict mycobacterial growth in macrophages. © 1990.

引用

页码：203 / 206

页数：4

共 18 条

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