A COMPARISON OF ADINAZOLAM AND DESIPRAMINE IN THE TREATMENT OF MAJOR DEPRESSION

被引：8

作者：

KENNEDY, SH ^{[1
]}

DEGROOT, J ^{[1
]}

RALEVSKI, E ^{[1
]}

REED, K ^{[1
]}

机构：

[1] UNIV TORONTO,QUEEN ST MENTAL HLTH CTR,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1991年 / 6卷 / 02期

关键词：

D O I：

10.1097/00004850-199100620-00001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thirty-one patients with a DSM-III (R) diagnosis of Major Depression received adinazolam (n = 16) or desipramine (n = 15) during a 6 week double-blind randomized controlled trial. Both groups showed a significant decline in Hamilton Rating Scale for Depression scores (21.8 +/- 4.5 to 10.7 +/- 8.5 for adinazolam and 23.5 +/- 5.5 to 12.9 +/- 8.6) for desipramine. Melancholic and anxiety symptoms were reduced equally by both drugs. Initial sedation was the most common side-effect with adinazolam. Plasma levels of desipramine and hydroxy-desipramine correlated highly with oral dose after 3 weeks of treatment.

引用

页码：65 / 76

页数：12

共 30 条

[1] AMSTERDAM JD, 1986, PSYCHOPHARMACOLOGY, V88, P484
[2] THE HAMILTON DEPRESSION SCALE - EVALUATION OF OBJECTIVITY USING LOGISTIC-MODELS
BECH, P
ALLERUP, P
GRAM, LF
REISBY, N
ROSENBERG, R
JACOBSEN, O
NAGY, A
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1981, 63 (03) : 290 - 299
[3] AN INVENTORY FOR MEASURING DEPRESSION
BECK, AT
ERBAUGH, J
WARD, CH
MOCK, J
MENDELSOHN, M
[J]. ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) : 561 - &
[4] BLIER P, 1987, J CLIN PSYCHOPHARM, V7, P245
[5] PLACEBO-RESPONSE IN DEPRESSION - A SEARCH FOR PREDICTORS
BROWN, WA
DORNSEIF, BE
WERNICKE, JF
[J]. PSYCHIATRY RESEARCH, 1988, 26 (03) : 259 - 264
[6] Checkley S., 1988, MELATONIN CLIN PERSP, P190
[7] COHN JB, 1988, J CLIN PSYCHIAT, V49, P142
[8] HOPKINS SYMPTOM CHECKLIST (HSCL) - SELF-REPORT SYMPTOM INVENTORY
DEROGATIS, LR
LIPMAN, RS
RICKELS, K
UHLENHUTH, EH
COVI, L
[J]. BEHAVIORAL SCIENCE, 1974, 19 (01): : 1 - 15
[9] DUNNER D, 1987, J CLIN PSYCHOPHARM, V7, P170
[10] COMPARISON OF ALPRAZOLAM, IMIPRAMINE, AND PLACEBO IN THE TREATMENT OF DEPRESSION
FEIGHNER, JP
ADEN, GC
FABRE, LF
RICKELS, K
SMITH, WT
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1983, 249 (22): : 3057 - 3064

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