PROTEOLYTIC MODIFICATION OF NEURAL CELL-ADHESION MOLECULE (NCAM) BY THE INTRACELLULAR PROTEINASE CALPAIN

被引：44

作者：

SHEPPARD, A

WU, J

RUTISHAUSER, U

LYNCH, G

机构：

[1] UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY,IRVINE,CA 92717

[2] CASE WESTERN RESERVE UNIV,DEPT GENET,CLEVELAND,OH 44106

[3] WASHINGTON UNIV,SCH MED,DEPT CELL BIOL & PHYSIOL,ST LOUIS,MO 63110

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1076卷 / 01期

关键词：

CALPAIN; NCAM; SYNAPTIC; PLASTICITY; CYTOSKELETON;

D O I：

10.1016/0167-4838(91)90234-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The neural cell adhesion molecule, NCAM, is concentrated in synaptic regions and thus may contribute to the formation and maintenance of connections between brain cells. We present evidence that the cytoplasmic domain of NCAM can be experimentally modified by the intracellular calcium-dependent proteinase, calpain. This degradation could provide a mechanism for rapidly uncoupling and reorganizing synaptic contacts.

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页码：156 / 160

页数：5

相关论文

共 18 条

[1] THE MEMBRANE SKELETON OF HUMAN-ERYTHROCYTES AND ITS IMPLICATIONS FOR MORE COMPLEX CELLS [J].

BENNETT, V .

ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 :273-304

[2] TRANSIENT AND ENDURING MORPHOLOGICAL CORRELATES OF SYNAPTIC ACTIVITY AND EFFICACY CHANGE IN THE RAT HIPPOCAMPAL SLICE [J].

CHANG, FLF ;

GREENOUGH, WT .

BRAIN RESEARCH, 1984, 309 (01) :35-46

[3] SYNAPTIC CORRELATES OF ASSOCIATIVE POTENTIATION DEPRESSION - AN ULTRASTRUCTURAL-STUDY IN THE HIPPOCAMPUS [J].

DESMOND, NL ;

LEVY, WB .

BRAIN RESEARCH, 1983, 265 (01) :21-30

[4] TOPOGRAPHY OF N-CAM STRUCTURAL AND FUNCTIONAL DETERMINANTS .2. PLACEMENT OF MONOCLONAL-ANTIBODY EPITOPES [J].

FRELINGER, AL ;

RUTISHAUSER, U .

JOURNAL OF CELL BIOLOGY, 1986, 103 (05) :1729-1737

[5] PHOSPHATIDYLINOSITOL IS INVOLVED IN THE MEMBRANE ATTACHMENT OF NCAM-120, THE SMALLEST COMPONENT OF THE NEURAL CELL-ADHESION MOLECULE [J].

HE, HT ;

BARBET, J ;

CHAIX, JC ;

GORIDIS, C .

EMBO JOURNAL, 1986, 5 (10) :2489-2494

[6] SEQUENCE OF A CDNA CLONE ENCODING THE POLYSIALIC ACID-RICH AND CYTOPLASMIC DOMAINS OF THE NEURAL CELL-ADHESION MOLECULE N-CAM [J].

HEMPERLY, JJ ;

MURRAY, BA ;

EDELMAN, GM ;

CUNNINGHAM, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (09) :3037-3041

[7] CDNA CLONES OF THE NEURAL CELL-ADHESION MOLECULE (N-CAM) LACKING A MEMBRANE-SPANNING REGION CONSISTENT WITH EVIDENCE FOR MEMBRANE ATTACHMENT VIA A PHOSPHATIDYLINOSITOL INTERMEDIATE [J].

HEMPERLY, JJ ;

EDELMAN, GM ;

CUNNINGHAM, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) :9822-9826

[8] MOLECULAR HETEROGENEITY AND STRUCTURAL EVOLUTION DURING CEREBELLAR ONTOGENY DETECTED BY MONOCLONAL-ANTIBODY OF THE MOUSE-CELL SURFACE-ANTIGEN BSP-2 [J].

HIRN, M ;

GHANDOUR, MS ;

DEAGOSTINIBAZIN, H ;

GORIDIS, C .

BRAIN RESEARCH, 1983, 265 (01) :87-100

[9]

HOFFMAN S, 1982, J BIOL CHEM, V257, P7720

[10] EVOLUTIONARY CONSERVATION OF KEY STRUCTURES AND BINDING FUNCTIONS OF NEURAL CELL-ADHESION MOLECULES [J].

HOFFMAN, S ;

CHUONG, CM ;

EDELMAN, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (21) :6881-6885