THE EFFECTS OF ASTEMIZOLE, CETIRIZINE AND LORATADINE ON THE TIME COURSE OF WEAL AND FLARE REACTIONS TO HISTAMINE, CODEINE AND ANTIGEN

被引：23

作者：

HUMPHREYS, F

HUNTER, JAA

机构：

[1] University Department of Dermatelogy, Royal Infirmary, Edinburgh

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1991年 / 125卷 / 04期

关键词：

D O I：

10.1111/j.1365-2133.1991.tb14173.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

An open cross-over study was performed to assess the effects of astemizole, cetirizine and loratadine on weal and flare reactions to intradermal histamine, codeine and house dust mite antigen. Percentage inhibition of weal area, flare area and weal volume was greatest for cetirizine, then astemizole and smallest for loratadine. Wealing due to mast-cell degranulation with either codeine or antigen was less inhibited by all three antihistamines than that due to histamine itself. Time-course studies revealed similarities between wealing provoked by codeine and histamine but different characteristics to that induced by antigen.

引用

页码：364 / 367

页数：4

共 10 条

[1] THE EFFECTS OF ASTEMIZOLE ON HISTAMINE-INDUCED WEAL AND FLARE [J].