MODIFICATION OF PROSTAGLANDIN METABOLISM INVIVO BY LONG-CHAIN OMEGA-3 POLYUNSATURATES

被引：16

作者：

FERRETTI, A

FLANAGAN, VP

机构：

[1] Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, ARS, Beltsville, MD

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1045卷 / 03期

关键词：

(Human); Diet supplementation; Docosahexaenoate; Fish oil; Icosapentaenoate; Prostaglandin E;

D O I：

10.1016/0005-2760(90)90134-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a pilot study conducted with a healthy male volunteer we determined that short-term dietary supplementation with fish oil markedly suppresses the systemic production of prostaglandin E (P = 0.04). This biochemical effect is observable after an incubation period of several days. The potential consequences of a reduced PGE synthetic rate on renal function, immune system and vascular dynamics, must be considered in the overall evaluation of the safety of fish oil supplements. © 1990.

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收藏

页码：299 / 301

页数：3

相关论文

共 18 条

[1] ARACHIDONIC-ACID STRONGLY STIMULATES PROSTAGLANDIN-I3 (PGI3) PRODUCTION FROM EICOSAPENTAENOIC ACID IN HUMAN-ENDOTHELIAL CELLS [J].

BORDET, JC ;

GUICHARDANT, M ;

LAGARDE, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 135 (02) :403-410

[2] STABLE ISOTOPE-DILUTION ASSAY FOR PROSTAGLANDIN-E METABOLITE - 24 HOUR URINARY OUTPUT IN HEALTHY MALE-SUBJECTS [J].

FERRETTI, A ;

FLANAGAN, VP ;

REEVES, VB .

ANALYTICAL BIOCHEMISTRY, 1987, 167 (01) :174-180

[3] OCCURRENCE OF PROSTAGLANDIN-E3 IN HUMAN-URINE AS A RESULT OF MARINE OIL INGESTION - GAS CHROMATOGRAPHIC-MASS SPECTROMETRIC EVIDENCE [J].

FERRETTI, A ;

FLANAGAN, VP ;

REEVES, VB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 959 (03) :262-268

[4] THROMBOXANE-A3 (TXA3) IS FORMED IN HUMAN-PLATELETS AFTER DIETARY EICOSAPENTAENOIC ACID (C2O-5-OMEGA-3) [J].

FISCHER, S ;

WEBER, PC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 116 (03) :1091-1099

[5] PROSTAGLANDIN-I3 IS FORMED INVIVO IN MAN AFTER DIETARY EICOSAPENTAENOIC ACID [J].

FISCHER, S ;

WEBER, PC .

NATURE, 1984, 307 (5947) :165-168

[6] DIETARY DOCOSAHEXAENOIC ACID IS RETROCONVERTED IN MAN TO EICOSAPENTAENOIC ACID, WHICH CAN BE QUICKLY TRANSFORMED TO PROSTAGLANDIN-I3 [J].

FISCHER, S ;

VISCHER, A ;

PREACMURSIC, V ;

WEBER, PC .

PROSTAGLANDINS, 1987, 34 (03) :367-375

[7] THROMBOXANE (TX)A3 AND PROSTAGLANDIN (PG)I3 ARE FORMED IN MAN AFTER DIETARY EICOSAPENTAENOIC ACID - IDENTIFICATION AND QUANTIFICATION BY CAPILLARY GAS-CHROMATOGRAPHY ELECTRON-IMPACT MASS-SPECTROMETRY [J].

FISCHER, S ;

WEBER, PC .

BIOMEDICAL MASS SPECTROMETRY, 1985, 12 (09) :470-476

[8] THE PROSTACYCLIN THROMBOXANE BALANCE IS FAVORABLY SHIFTED IN GREENLAND ESKIMOS [J].

FISCHER, S ;

WEBER, PC ;

DYERBERG, J .

PROSTAGLANDINS, 1986, 32 (02) :235-241

[9]

HAMBERG M, 1971, J BIOL CHEM, V246, P6713

[10]

HORNSTRA G, 1983, ADV PROSTAG THROMB L, V12, P193