A MATRIX-ASSISTED LASER DESORPTION TIME-OF-FLIGHT MASS-SPECTROMETER BASED ON A 600-PS, 1.2 MJ NITROGEN LASER

被引:23
作者
CHEVRIER, MR [1 ]
COTTER, RJ [1 ]
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,MIDDLE ATLANTIC MASS SPECTROMETRY LAB,BALTIMORE,MD 21205
关键词
D O I
10.1002/rcm.1290051209
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The design and performance of a short-pulse UV laser desorption time-of-flight mass spectrometer is described. The instrument combines the advantages of a 600 ps, 337 nm pulsed nitrogen laser with a compact, high-voltage extraction linear time-of-flight analyzer. A number of peptides and proteins have been analyzed to demonstrate sensitivity, high mass range, resolution and mixture analysis.
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页码:611 / 617
页数:7
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