QUANTITATIVE MAGNETIC-RESONANCE-IMAGING OF HUMAN BRAIN PERFUSION AT 1.5-T USING STEADY-STATE INVERSION OF ARTERIAL WATER

被引：147

作者：

ROBERTS, DA ^{[1
]}

DETRE, JA ^{[1
]}

BOLINGER, L ^{[1
]}

INSKO, EK ^{[1
]}

LEIGH, JS ^{[1
]}

机构：

[1] UNIV PENN,DEPT NEUROL,PHILADELPHIA,PA 19104

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 01期

关键词：

CEREBRAL BLOOD FLOW; FUNCTIONAL IMAGING; ADIABATIC FAST PASSAGE; NUCLEAR MAGNETIC RESONANCE IN-VIVO;

D O I：

10.1073/pnas.91.1.33

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report our experience using a noninvasive magnetic resonance technique for quantitative imaging of human brain perfusion at 1.5 T. This technique uses magnetically inverted arterial water as a freely diffusible blood flow tracer. A perfusion image is calculated from magnetic resonance images acquired with and without arterial blood inversion and from an image of the apparent spin-lattice relaxation time. Single-slice perfusion maps were obtained from nine volunteers with approximately 1 x 2 x 5-mm resolution in an acquisition time of 15 min. Analysis yielded average perfusion rates of 93 +/- 16 ml.100 g-1.min-1 for gray matter, 38 +/- 10 ml.100 g-1.min-1 for white matter, and 52 +/- 8 ml.100 g-1.min-1 for whole brain. Significant changes in perfusion were observed during hyperventilation and breath holding. This technique may be used for quantitative measurement of perfusion in human brain without the risks and expense of methods which use exogenous tracers.

引用

页码：33 / 37

页数：5

共 29 条

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