CHEMOSELECTIVE REMOVAL AND REPLACEMENT OF THE C-4' AND C-6 ACYL ESTERS OF ZARAGOZIC ACID-A

被引：13

作者：

BURK, RM

BERGER, GD

BUGIANESI, RL

GIROTRA, NN

PARSONS, WH

PONPIPOM, MM

机构：

[1] Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)77469-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient chemical sequence is described for the modification of the C-4' and C-6 positions of zaragozic acid A. Key reactions include the specific conditions devised for selective removal of either the C-4' acetate or the C-6 acyl chain. The resultant hydroxy intermediates were then derivatized as esters, ethers, carbamates, and carbonates.

引用

页码：975 / 978

页数：4

共 8 条

[1]

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[2]

BERTSTROM JD, 1992, UNPUB P NAT ACAD SCI

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