MULTIPLE BINDING MODES WITH DNA OF ANTHRACENE-9-CARBONYL-N-1-SPERMINE PROBED BY LD, CD, NORMAL ABSORPTION, AND MOLECULAR MODELING COMPARED WITH THOSE OF SPERMIDINE AND SPERMINE

被引：17

作者：

ADLAM, G

BLAGBROUGH, IS

TAYLOR, S

LATHAM, HC

HAWORTH, IS

RODGER, A

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,BATH BA2 7AY,AVON,ENGLAND

[2] UNIV OXFORD,PHYS CHEM LAB,OXFORD OX1 3QZ,ENGLAND

[3] UNIV SO CALIF,DEPT PHARMACEUT SCI,LOS ANGELES,CA 90033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(01)80405-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N-1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N-1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.

引用

页码：2435 / 2440

页数：6

共 15 条

[1] INVESTIGATIONS OF THE MECHANISM BY WHICH MAMMALIAN-CELL GROWTH IS INHIBITED BY N1N12-BIS(ETHYL)SPERMINE [J].