GP80 (CLUSTERIN, TRPM-2) MESSENGER-RNA LEVEL IS ENHANCED IN HUMAN RENAL CLEAR-CELL CARCINOMAS

被引：63

作者：

PARCZYK, K

PILARSKY, C

RACHEL, U

KOCHBRANDT, C

机构：

[1] UNIV MAINZ,INST BIOCHEM,D-55099 MAINZ,GERMANY

[2] SCHERING AG,D-13342 BERLIN,GERMANY

[3] UNIV KLINIKUM FRANKFURT,ZENTRUM CHIRURG,UROL ABT,D-60596 FRANKFURT,GERMANY

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1994年 / 120卷 / 03期

关键词：

KIDNEY TUMORS; NEOPLASTIC GENE EXPRESSION; CELL DEATH; COMPLEMENT INHIBITION; CLUSTERIN;

D O I：

10.1007/BF01202200

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The gp80 glycoprotein complex (clusterin, apolipoprotein J, TRPM-2) is a widely expressed protein that has been attributed functions in tissue remodelling, immune defense and transport of lipids and biologically active peptides. The expression of the protein appears to be elevated in several neurodegenerative, apoptotic and malignant processes. We show here that in patients with renal clear cell carcinoma gp80 mRNA is 3-fold overexpressed in tissue of the tumors compared with adjacent non-tumor tissue.

引用

页码：186 / 188

页数：3

共 21 条

[1]

Bowen ID, 1990, PROGRAMMED CELL DEAT

[2] INDUCTION OF THE TRPM-2 GENE IN CELLS UNDERGOING PROGRAMMED DEATH [J].