NEW SELECTIVE BRADYKININ RECEPTOR ANTAGONISTS AND BRADYKININ-B2 RECEPTOR CHARACTERIZATION

被引：170

作者：

REGOLI, D

RHALEB, NE

DION, S

DRAPEAU, G

机构：

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0165-6147(90)90067-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Substantial progress has been made recently in the field of kinin pharmacology with the identification of sensitive bioassay organs and the discovery of bradykinin B2 receptor antagonists. Data obtained with such compounds in various laboratories support the hypothesis that kinins act on multiple (at least two) receptor types. Domenico Regoli and colleagues review here the basic criteria of receptor characterization as they apply to kinins and present a critical analysis of the bioassay organs and B2 receptor antagonists currently used in kinin pharmacology. © 1990.

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页码：156 / 161

页数：6

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