CHROMATOGRAPHY WITH METAL SPECIFIC DETECTION OF URINE SAMPLES FROM AN ARTHRITIS PATIENT ON AURANOFIN THERAPY

Six sequential urine samples obtained from a patient on auranofin therapy were analyzed for total gold, zinc, copper and creatinine levels. They were separated by high performance liquid chromatography (HPLC) on a weak anion exchange column. The detector utilized was an inductively coupled plasma mass spectrometer (ICP-MS). Five, gold-containing metabolites as well as multiple zinc- and copper-containing materials were eluted. The distribution of all three metals changed with time on therapy. © 1990, Taylor & Francis Group, LLC. All rights reserved.