CHROMATOGRAPHY WITH METAL SPECIFIC DETECTION OF URINE SAMPLES FROM AN ARTHRITIS PATIENT ON AURANOFIN THERAPY

被引:13
作者
ELDER, RC
TEPPERMAN, K
TARVER, ML
MATZ, S
JONES, WB
HESS, EV
机构
[1] UNIV CINCINNATI,BIOMED CHEM RES CTR,CINCINNATI,OH 45221
[2] UNIV CINCINNATI,DEPT BIOL SCI,CINCINNATI,OH 45221
[3] UNIV CINCINNATI,DEPT INTERNAL MED,DIV IMMUNOL,CINCINNATI,OH 45221
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 06期
基金
美国国家卫生研究院;
关键词
D O I
10.1080/01483919008049242
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Six sequential urine samples obtained from a patient on auranofin therapy were analyzed for total gold, zinc, copper and creatinine levels. They were separated by high performance liquid chromatography (HPLC) on a weak anion exchange column. The detector utilized was an inductively coupled plasma mass spectrometer (ICP-MS). Five, gold-containing metabolites as well as multiple zinc- and copper-containing materials were eluted. The distribution of all three metals changed with time on therapy. © 1990, Taylor & Francis Group, LLC. All rights reserved.
引用
收藏
页码:1191 / 1202
页数:12
相关论文
共 11 条