T-CELL ACTIVATION AND ANTIGEN PRESENTATION IN HUMAN THYROID AUTOIMMUNITY

被引：22

作者：

FELDMANN, M ^{[1
]}

DAYAN, C ^{[1
]}

RAPOPORT, B ^{[1
]}

LONDEI, M ^{[1
]}

机构：

[1] VET ADM MED CTR,THYROID MOLEC BIOL 111T,SAN FRANCISCO,CA 94121

来源：

JOURNAL OF AUTOIMMUNITY | 1992年 / 5卷

关键词：

D O I：

10.1016/0896-8411(92)90026-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1983, a hypothesis concerning the relevance of class II expression and antigen presentation to the induction and maintenance of endocrine autoimmunity was published. This article reviews the evidence that has been marshalled to support this concept, both in man, chiefly in Graves' disease, and in murine systems. New data concerning the multiplicity of thyroid autoantigens recognized by in vivo activated thyroid infiltrating T cells are compatible with this concept since the thyroid epithelial cells are the source of these antigens. Whether other autoimmune diseases also employ the same mechanism remains to be ascertained, as does the initial trigger for the autoimmune process. © 1992.

引用

页码：115 / 121

页数：7

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