EFFECT OF POLYMORPHISM OF AN MHC-LINKED TRANSPORTER ON THE PEPTIDES ASSEMBLED IN A CLASS-I MOLECULE

被引：359

作者：

POWIS, SJ ^{[1
]}

DEVERSON, EV ^{[1
]}

COADWELL, WJ ^{[1
]}

CIRUELA, A ^{[1
]}

HUSKISSON, NS ^{[1
]}

SMITH, H ^{[1
]}

BUTCHER, GW ^{[1
]}

HOWARD, JC ^{[1
]}

机构：

[1] AFRC,INST ANIM PHYSIOL & GENET RES,MICROCHEM FACIL,CAMBRIDGE CB2 4AT,ENGLAND

来源：

NATURE | 1992年 / 357卷 / 6375期

关键词：

D O I：

10.1038/357211a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.

引用

页码：211 / 215

页数：5

共 45 条

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