DECREASE OF HIPPOCAMPAL CHOLINE-ACETYLTRANSFERASE ACTIVITY-INDUCED BY FORMALIN PAIN

被引：15

作者：

ALOISI, AM

ALBONETTI, ME

LODI, L

LUPO, C

CARLI, G

机构：

[1] Istituto di Fisiologia Umana, Università degli Studi di Siena, I-53100 Seina

来源：

BRAIN RESEARCH | 1993年 / 629卷 / 01期

关键词：

FORMALIN TEST; CHOLINE ACETYLTRANSFERASE (CHAT); HIPPOCAMPUS; PAIN;

D O I：

10.1016/0006-8993(93)90498-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of the hippocampal choline acetyltransferase (ChAT) activity in the response to tonic pain was investigated in rats injected with formalin, either 50 mul 10% or 50 mul 0.1%. Hippocampal ChAT activity was found to be reduced both 30 and 60 min after injection of the higher concentration of formalin but only 30 min after the lower one. Results indicate that the decrease in ChAT activity depends upon the presence of the nociceptive input rather than its magnitude. The hippocampal formation is involved in the specific behavioural response to pain, namely licking.

引用

页码：167 / 170

页数：4

共 24 条

[1] BRAIN-STEM LESIONS DISSOCIATE NEURAL MECHANISMS OF MORPHINE ANALGESIA IN DIFFERENT KINDS OF PAIN [J].