HIV-SPECIFIC CD8+ T-CELL IMMUNE-RESPONSES AND VIRAL REPLICATION

被引：19

作者：

BUSEYNE, F

RIVIERE, Y

机构：

来源：

AIDS | 1993年 / 7卷

关键词：

HIV INFECTION; CD8+ T CELLS; HIV-SPECIFIC CYTOTOXIC T LYMPHOCYTES;

D O I：

10.1097/00002030-199311002-00016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: To review current knowledge of CD8+ T cells in relation to their effect on the replication of HIV and on disease progression. Present knowledge: Both CD8+ cytotoxic T lymphocytes capable of killing cells expressing HIV antigens and CD8+ lymphocytes that suppress HIV replication in vitro are detectable in response to HIV infection. Conclusion: These CD8+ T cells may help to maintain a low viral load in vivo, thus allowing a long asymptomatic period of infection.

引用

页码：S81 / S85

页数：5

共 42 条

[1]

BRINCHMANN JE, 1990, J IMMUNOL, V144, P2961

[2]

BUSEYNE F, 1993, J IMMUNOL, V150, P3569

[3] QUANTITATIVE-ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-SPECIFIC CYTOTOXIC LYMPHOCYTE-T (CTL) RESPONSE AT DIFFERENT STAGES OF HIV-1 INFECTION - DIFFERENTIAL CTL RESPONSES TO HIV-1 AND EPSTEIN-BARR-VIRUS IN LATE DISEASE [J].