ASCORBIC-ACID REDUCES THE ENDOTOXIN-INDUCED LUNG INJURY IN AWAKE SHEEP

被引：32

作者：

DWENGER, A ^{[1
]}

PAPE, HC ^{[1
]}

BANTEL, C ^{[1
]}

SCHWEITZER, G ^{[1
]}

KRUMM, K ^{[1
]}

GROTZ, M ^{[1
]}

LUEKEN, B ^{[1
]}

FUNCK, M ^{[1
]}

REGEL, G ^{[1
]}

机构：

[1] HANNOVER MED SCH,UNFALLCHIRURG KLIN,D-30625 HANNOVER,GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 24卷 / 04期

关键词：

ACUTE LUNG INJURY; ASCORBIC ACID; ENDOTOXIN; SHEEP;

D O I：

10.1111/j.1365-2362.1994.tb01079.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our aim was to investigate whether ascorbic acid can reduce reactive oxygen metabolite-mediated acute lung injury. The effects of intravenous administration of Escherichia coli endotoxin were studied, with and without ascorbic acid infusion, on haemodynamics, lung lymph flow, cardio-respiratory and neutrophil function in chronically instrumented sheep. Paired experiments were performed on eight sheep in which they received either endotoxin alone (0.5 mu g kg(-1) b.w.) (ET group) or in combination with an ascorbic acid infusion (1 g kg(-1) b.w. bolus injection followed by 0.2 g kg(-1) h(-1) continuous infusion) (ET + ASC group) in random order. Four of the animals also received ascorbic acid alone (ASC group).

引用

页码：229 / 235

页数：7

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