THE ORPHAN RECEPTOR FAMILY RZR/ROR, MELATONIN AND 5-LIPOXYGENASE - AN UNEXPECTED RELATIONSHIP

被引:163
作者
CARLBERG, C [1 ]
WIESENBERG, I [1 ]
机构
[1] CIBA GEIGY AG, PHARMA FORSCH, CH-4002 BASEL, SWITZERLAND
关键词
NUCLEAR HORMONE RECEPTORS; LIGAND IDENTIFICATION; GENE REGULATION; NATURAL RESPONDING GENES; NUCLEAR SIGNALING OF MELATONIN;
D O I
10.1111/j.1600-079X.1995.tb00157.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The orphan receptors RZR alpha, RZR beta, ROR alpha 1, RZR alpha 2, ROR alpha 3, and ROR gamma form a subfamily within the superfamily of nuclear hormone receptors. Recently, experimental evidence that the pineal gland hormone melatonin is the natural ligand for these nuclear receptors has come to light. This discovery is rather surprising, given that most people in the field believed melatonin acts exclusively through membrane receptors. However, these new findings establish a nuclear signalling pathway for melatonin, i.e., direct ligand-induced control of target gene transcription, which most probably mediates part of the physiological functions of the hormone. Interestingly, the very recently identified first RZR/melatonin responding gene, 5-lipoxygenase, is not expressed in the brain and is not involved in circadian rhythmicity, but rather acts in the periphery, mainly in myeloid cells, as one of the key enzymes of allergic and inflammatory reactions. Thus, nuclear melatonin signalling opens up a new perspective in understanding the actions of the pineal gland hormone.
引用
收藏
页码:171 / 178
页数:8
相关论文
共 51 条
  • [1] CHARACTERIZATION OF HIGH-AFFINITY MELATONIN BINDING-SITES IN PURIFIED CELL-NUCLEI OF RAT-LIVER
    ACUNACASTROVIEJO, D
    REITER, RJ
    MENENDEZPELAEZ, A
    PABLOS, MI
    BURGOS, A
    [J]. JOURNAL OF PINEAL RESEARCH, 1994, 16 (02) : 100 - 112
  • [2] ACUNACASTROVIEJO D, 1993, RES COMMUN CHEM PATH, V82, P253
  • [3] ALLENBY G, 1994, J BIOL CHEM, V269, P16689
  • [4] RETINOIC ACID RECEPTORS AND RETINOID X-RECEPTORS - INTERACTIONS WITH ENDOGENOUS RETINOIC ACIDS
    ALLENBY, G
    BOCQUEL, MT
    SAUNDERS, M
    KAZMER, S
    SPECK, J
    ROSENBERGER, M
    LOVEY, A
    KASTNER, P
    GRIPPO, JF
    CHAMBON, P
    LEVIN, AA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) : 30 - 34
  • [5] IDENTIFICATION OF NUCLEAR RECEPTOR MESSENGER-RNAS BY RT-PCR AMPLIFICATION OF CONSERVED ZINC-FINGER MOTIF SEQUENCES
    BECKERANDRE, M
    ANDRE, E
    DELAMARTER, JF
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (03) : 1371 - 1379
  • [6] BECKERANDRE M, 1994, J BIOL CHEM, V269, P28531
  • [7] BLASK DE, 1986, J NEURAL TRANSM, P433
  • [8] BONNELYE E, 1994, CELL GROWTH DIFFER, V5, P1357
  • [9] RZRS, A NEW FAMILY OF RETINOID-RELATED ORPHAN RECEPTORS THAT FUNCTION AS BOTH MONOMERS HOMODIMERS
    CARLBERG, C
    VANHUIJSDUIJNEN, RH
    STAPLE, JK
    DELAMARTER, JF
    BECKERANDRE, M
    [J]. MOLECULAR ENDOCRINOLOGY, 1994, 8 (06) : 757 - 770
  • [10] 2 NUCLEAR SIGNALING PATHWAYS FOR VITAMIN-D
    CARLBERG, C
    BENDIK, I
    WYSS, A
    MEIER, E
    STURZENBECKER, LJ
    GRIPPO, JF
    HUNZIKER, W
    [J]. NATURE, 1993, 361 (6413) : 657 - 660