METHOTREXATE ANALOGS .19. REPLACEMENT OF THE GLUTAMATE SIDE-CHAIN IN CLASSICAL ANTIFOLATES BY L-HOMOCYSTEIC ACID AND L-CYSTEIC ACID - EFFECT ON ENZYME-INHIBITION AND ANTITUMOR-ACTIVITY

被引：42

作者：

ROSOWSKY, A

FORSCH, RA

FREISHEIM, JH

MORAN, RG

WICK, M

机构：

[1] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA 02115

[3] UNIV CINCINNATI,MED CTR,DEPT BIOL CHEM,CINCINNATI,OH 45267

[4] CHILDRENS HOSP,DIV HEMATOL ONCOL,LOS ANGELES,CA 90027

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1984年 / 27卷 / 05期

关键词：

D O I：

10.1021/jm00371a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：600 / 604

页数：5

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