PHARMACOKINETICS OF METHOTREXATE ADMINISTERED BY INTRAMUSCULAR AND SUBCUTANEOUS INJECTIONS IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：85

作者：

BROOKS, PJ ^{[1
]}

SPRUILL, WJ ^{[1
]}

PARISH, RC ^{[1
]}

BIRCHMORE, DA ^{[1
]}

机构：

[1] UNIV GEORGIA,COLL PHARM,DEPT PHARM PRACTICE,ATHENS,GA 30602

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 01期

关键词：

D O I：

10.1002/art.1780330112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The serum concentrations and the pharmacokinetics of low‐dose methotrexate (MTX) were compared after both intramuscular (IM) and subcutaneous (SQ) injections in 5 patients with rheumatoid arthritis. Values for the observed peak concentration, the time to the observed peak concentration, and the area under the time versus concentration curve for IM injections were not significantly different from these values for SQ injections. These results suggest that IM and SQ are interchangeable routes of administration. SQ administration may be a more convenient and less painful way of administering low‐dose MTX. Copyright © 1990 American College of Rheumatology

引用

页码：91 / 94

页数：4

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